کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8652008 | 1573344 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with higher-grade cancers and worse clinical prognosis. We evaluated the effects of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was moderated by syndecan-1. We also demonstrate that syndecan-1 (or lack thereof) alters the miRNA cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identified a distinct shift toward augmented procancer signaling consistent with the changes found in lung adenocarcinoma. Collectively, our work identifies syndecan-1 as an important factor in lung cancer cells that shapes the tumor microenvironment through alterations in miRNA packaging within exosomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 188, Issue 4, April 2018, Pages 1094-1103
Journal: The American Journal of Pathology - Volume 188, Issue 4, April 2018, Pages 1094-1103
نویسندگان
Tanyalak Parimon, Rena Brauer, Saundra Y. Schlesinger, Ting Xie, Dianhua Jiang, Lingyin Ge, Ying Huang, Timothy P. Birkland, William C. Parks, David M. Habiel, Cory M. Hogaboam, Sina A. Gharib, Nan Deng, Zhenqui Liu, Peter Chen,