کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8652008 1573344 2018 37 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes
چکیده انگلیسی
Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with higher-grade cancers and worse clinical prognosis. We evaluated the effects of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was moderated by syndecan-1. We also demonstrate that syndecan-1 (or lack thereof) alters the miRNA cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identified a distinct shift toward augmented procancer signaling consistent with the changes found in lung adenocarcinoma. Collectively, our work identifies syndecan-1 as an important factor in lung cancer cells that shapes the tumor microenvironment through alterations in miRNA packaging within exosomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 188, Issue 4, April 2018, Pages 1094-1103
نویسندگان
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