کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8660145 | 1575740 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Predicting arrhythmic risk in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis
ترجمه فارسی عنوان
پیش بینی خطر آریتمی در کاردیومیوپاتی بطنی آرتروژنی: بررسی منظم و متاآنالیز
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کلمات کلیدی
کاردیومیوپاتی بطن چپ قلبی آریتمی دیستپلازی بطنی راست / قلب و عروق آریتمی مغز، متاآنالیز، طبقه بندی خطر، پیش بینی، مرگ ناگهانی قلب، بررسی سیستماتیک، آریتمی های بطنی،
Ventricular arrhythmias - آریتمی بطنیArrhythmogenic right ventricular dysplasia/cardiomyopathy - دیسپلازی بطنی راست / قلب و عروق کرونریRisk stratification - طبقه بندی خطرMeta-analysis - فرا تحلیل Systematic review - مرور سیستماتیکSudden cardiac death - مرگ ناگهانی قلبیprognosis - پیش شناخت بیماریArrhythmogenic right ventricular cardiomyopathy - کاردیومیوپاتی بطن چپ قلبی آریتمی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
While many studies evaluate predictors of ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC), a systematic review consolidating this evidence is currently lacking. Therefore, we searched MEDLINE and Embase for studies analyzing predictors of ventricular arrhythmias (sustained ventricular tachycardia/fibrillation (VT/VF), appropriate implantable cardioverter-defibrillator therapy, or sudden cardiac death) in patients with definite ARVC, patients with borderline ARVC, and ARVC-associated mutation carriers. In the case of multiple publications on the same cohort, the study with the largest population was included. This yielded 45 studies with a median cohort size of 70 patients (interquartile range 60 patients) and a median follow-up of 5.0 years (interquartile range 3.3 - 6.7 years). The average proportion of arrhythmic events observed was 10.6%/y in patients with definite ARVC, 10.0%/y in patients with borderline ARVC, and 3.7%/y with mutation carriers. Predictors of ventricular arrhythmias were population dependent: consistently predictive risk factors in patients with definite ARVC were male sex, syncope, T-wave inversion in lead >V3, right ventricular dysfunction, and prior (non)sustained VT/VF; in patients with borderline ARVC, 2 additional predictors-inducibility during electrophysiology study and strenuous exercise-were identified; and with mutation carriers, all aforementioned predictors as well as ventricular ectopy, multiple ARVC-related pathogenic mutations, left ventricular dysfunction, and palpitations/presyncope determined arrhythmic risk. Most evidence originated from small observational cohort studies, with a moderate quality of evidence. In conclusion, the average risk of ventricular arrhythmia ranged from 3.7 to 10.6%/y depending on the population with ARVC. Male sex, syncope, T-wave inversion in lead >V3, right ventricular dysfunction, and prior (non)sustained VT/VF consistently predict ventricular arrhythmias in all populations with ARVC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Heart Rhythm - Volume 15, Issue 7, July 2018, Pages 1097-1107
Journal: Heart Rhythm - Volume 15, Issue 7, July 2018, Pages 1097-1107
نویسندگان
Laurens P. MD, Arjan BSc, Cynthia A. PhD, ScM, Julia MD, Hugh MD, FHRS, J. Peter MD, PhD, Richard N.W. MD, PhD, Folkert W. MD, PhD, Anneline S.J.M. MD, PhD,