Multiplexed bioactive paper based on GO@SiO2@CeO2 nanosheets for a low-cost diagnostics platform

• GO@SiO2@CeO2 hybrid nanosheets with intrinsic peroxidase-like activity were successfully synthesized.
• GSCs have great potential as an alternative to the commonly employed peroxidase.
• An easy colorimetric bioactive paper was fabricated based on GSCs.
• Glucose, lactate, uric acid and cholesterol can be well detected by the naked eyes.

In this paper, Graphene oxide@SiO2@CeO2 hybrid nanosheets (GSCs) have been successfully synthesized by the wet-chemical strategy. TEM, FITR and XPS were applied to characterize the morphology and composition of the nanosheets. The colorimetric assay of these nanosheets indicated that they possessed high intrinsic peroxidase activity, which should be ascribed to the combination of graphene oxide and CeO2. A fully integrated reagentless bioactive paper based on GSCs was fabricated, which were able to simultaneously detect glucose, lactate, uric acid and cholesterol. The results demonstrated that GSCs have great potential as an alternative to the commonly employed peroxidase in daily nursing and general physical examination.