کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8668386 | 1578164 | 2018 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Undetectable high-density lipoprotein cholesterol in acute malaria
ترجمه فارسی عنوان
کلسترول لیپوپروتئین با چگالی غیر قابل تشخیص در مالاریای حاد
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
We report the case of a 39-year-old West African man in whom high-density lipoprotein cholesterol (HDL-C) was identified as undetectable at <0.08Â mmol/L. Total cholesterol in the same sample was 2.85Â mmol/L; triglycerides were only mildly elevated at 2.32Â mmol/L. He was admitted with a 2-week history of polydipsia, polyuria, weight loss and hyperpyrexia. Dual malarial infection with Plasmodium ovale and falciparum was identified and attributed to a recent trip to Nigeria without chemoprophylaxis. Also, he was diagnosed with diabetes mellitus with random hyperglycemia of 39Â mmol/L but no ketonemia. Subsequent investigation revealed a low apolipoprotein A1 of 0.38Â g/L (1.04-2.02), confirming a true HDL-C deficit. On clinical examination, he had neither orange tonsils consistent with Tangier disease nor corneal opacification consistent with lecithin-cholesterol acyltransferase deficiency. The patient was an avid gym goer but denied anabolic steroid abuse, a fact supported by a transient primary testosterone deficiency at presentation (testosterone 6.56Â nmol/L, RR 8.6-29; follicle-stimulating hormone high at 9.2 mU/L, luteinising hormone high at 11.9 mU/L). He was treated for malaria and started on metformin for diabetes. At 8-week follow-up, his HDL-C was entirely normal at 1.38Â mmol/L. We believe this severe drop in HDL-C level to be due to acute inflammation caused by malaria. As extreme drops in HDL-C have been found to be associated with the poorest prognosis, prospective identification of HDL-C and prompt clinical liaison may be of benefit.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Lipidology - Volume 12, Issue 3, MayâJune 2018, Pages 822-825
Journal: Journal of Clinical Lipidology - Volume 12, Issue 3, MayâJune 2018, Pages 822-825
نویسندگان
Ana MD, FRCPath, MRCPI, MRCP(UK), Vivion Edward Francis MB, MSc, FRCPath, FFPath(RCPI), FRCPI, Martin Andrew BSc, MB BS, MA (medical ethics and law), PhD, FRCPath, FRCPI, FRCP,