کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8674285 | 1578865 | 2018 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction](/preview/png/8674285.png)
چکیده انگلیسی
These studies are the first to elucidate ACSL4's in vivo actions to regulate the incorporation of AA into PL and downstream effects on DIO-associated adipocyte dysfunction. By reducing the incorporation of AA into PL and free fatty acid pools in adipocytes, Ad-KO mice were significantly protected against HFD-induced increases in adipose and liver fat accumulation, adipocyte death, gonadal white adipose tissue (gWAT) inflammation, and insulin resistance (IR). Additionally, deficiency of adipocyte ACSL4 expression in mice fed a HFD resulted in increased gWAT adipocyte OCR and whole body energy expenditure (EE).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Metabolism - Volume 9, March 2018, Pages 43-56
Journal: Molecular Metabolism - Volume 9, March 2018, Pages 43-56
نویسندگان
Elizabeth A. Killion, Andrew R. Reeves, Mahmoud A. El Azzouny, Qing-Wu Yan, Defne Surujon, John D. Griffin, Thomas A. Bowman, Chunyan Wang, Nirupa R. Matthan, Eric L. Klett, Dong Kong, John W. Newman, Xianlin Han, Mi-Jeong Lee, Rosalind A. Coleman,