کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
867613 | 1470992 | 2011 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids A viscosity-dependent affinity sensor for continuous monitoring of glucose in biological fluids](/preview/png/867613.png)
We present a viscometric affinity biosensor for continuous monitoring of glucose in biological fluids such as blood and plasma. The sensing principle of this chemico-mechanical sensor is based upon the viscosity variation of a sensitive fluid with glucose concentration. Basically, this device includes both an actuating and a sensing piezoelectric diaphragms as well as a flow-resistive microchannel. In order to confine the sensitive fluid and allow glucose diffusion into the sensor, a free-standing alumina nanoporous membrane is also used as size-selective interface. Measurements carried out at nominal temperatures of 25 and 37 °C reveal that this sensor topology exhibits a high resolution in the current range of physiological blood glucose concentrations, i.e. 2–20 mM. In addition, complete reversibility was also demonstrated for at least 3 days. Finally, measurements performed in human blood serum confirm that this sensor fulfils all basic requirements for a use in continuous glucose monitoring of biological fluids.
► We developed and tested a viscosity-based glucose sensor.
► A high accuracy was demonstrated in the physiological range of glucose.
► A good reversibility and stability was demonstrated for up to 3 days.
► Promising results were obtained in human blood serum.
Journal: Biosensors and Bioelectronics - Volume 30, Issue 1, 15 December 2011, Pages 223–228