کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
867734 | 909791 | 2011 | 5 صفحه PDF | دانلود رایگان |

This paper describes a sensor for label-free, fully electrical detection of DNA hybridization based on capacitive changes in the electrode–electrolyte interface. The sensor measures capacitive changes in real time according to a charging–discharging principle that is limited by the hysteresis window. In addition, a novel autonomous searching technique, which exclusively monitors desorption-free hybridized electrodes among electrode arrays, enhances the performance of the sensor compared with conventional capacitive measurement. The sensor system achieves a detection range of 80 dB. The integrated circuit sensor is fabricated with a 0.35 μm CMOS process. The proposed sensor offers rapid, robust and inexpensive measurement of capacitance with highly integrated detection circuitry. It also facilitates quantitative evaluations of molecular densities on a chip with distinctive impedance variations by monitoring desorption-free hybridized electrodes. Our electrical biosensor has great potential for use with bio analytical tools and point-of-care diagnosis.
Journal: Biosensors and Bioelectronics - Volume 26, Issue 11, 15 July 2011, Pages 4591–4595