کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
867734 909791 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization
چکیده انگلیسی

This paper describes a sensor for label-free, fully electrical detection of DNA hybridization based on capacitive changes in the electrode–electrolyte interface. The sensor measures capacitive changes in real time according to a charging–discharging principle that is limited by the hysteresis window. In addition, a novel autonomous searching technique, which exclusively monitors desorption-free hybridized electrodes among electrode arrays, enhances the performance of the sensor compared with conventional capacitive measurement. The sensor system achieves a detection range of 80 dB. The integrated circuit sensor is fabricated with a 0.35 μm CMOS process. The proposed sensor offers rapid, robust and inexpensive measurement of capacitance with highly integrated detection circuitry. It also facilitates quantitative evaluations of molecular densities on a chip with distinctive impedance variations by monitoring desorption-free hybridized electrodes. Our electrical biosensor has great potential for use with bio analytical tools and point-of-care diagnosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 26, Issue 11, 15 July 2011, Pages 4591–4595
نویسندگان
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