کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8678595 | 1579100 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Classification et prise en charge thérapeutique des gammapathies monoclonales de signification rénale
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کلمات کلیدی
Amylose ALAL amyloidosis - AL آمیلوئیدوزMonoclonal immunoglobulin - ایمونوگلوبولین منوکلونالImmunoglobuline monoclonale - ایمونوگلوبولینهای مونوکلونالMonoclonal immunoglobulin deposition disease - بیماری انقباض ایمونوگلوبولین مونوکلونالfree light chains - زنجیرهای آزاد رایگانKidney failure - نارسایی کلیهInsuffisance rénale - نارسایی کلیوی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Classification et prise en charge thérapeutique des gammapathies monoclonales de signification rénale Classification et prise en charge thérapeutique des gammapathies monoclonales de signification rénale](/preview/png/8678595.png)
چکیده انگلیسی
Two categories of renal disorders associated with monoclonal gammopathies are to be distinguished, according to the characteristics of the underlying B-cell clone. The first group of renal diseases always occurs in the setting of high tumor mass with production of large amounts of monoclonal immunoglobulins. The main complication is the so-called myeloma cast nephropathy, which almost invariably complicates high tumor mass myeloma. The second group includes all renal disorders caused by a monoclonal immunoglobulin secreted by a nonmalignant B-cell clone, and currently referred as a “monoclonal gammopathy of renal significance (MGRS)”. This term was introduced to distinguish monoclonal gammopathies that are responsible for the development of kidney damage from those that are truly benign. The spectrum of renal diseases in MGRS is wide and its classification relies on the localization of renal lesions, either glomerular or tubular, and on the pattern of ultrastructural organization of immunoglobulin deposits. Physicochemical characteristics of the pathogenic monoclonal immunoglobulin are probably involved in their propensity to deposit or precipitate in the kidney, as illustrated by the high rate of recurrence of each specific type after kidney transplantation. Early diagnosis and efficient chemotherapy targeting the causal B-cell clone are mandatory to improve renal prognosis and patient survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: La Revue de Médecine Interne - Volume 39, Issue 3, March 2018, Pages 161-170
Journal: La Revue de Médecine Interne - Volume 39, Issue 3, March 2018, Pages 161-170
نویسندگان
V. Javaugue, I. Bouteau, C. Sirac, N. Quellard, J. Diolez, A. Colombo, E. Desport, L. Ecotière, J.-M. Goujon, J.-P. Fermand, G. Touchard, A. Jaccard, F. Bridoux,