کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8679783 1579228 2018 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondrial quality control: The role of mitophagy in aging
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Mitochondrial quality control: The role of mitophagy in aging
چکیده انگلیسی
Autophagy is a catabolic process for eliminating macromolecules and damaged organelles by a highly regulated lysosomal pathway. Importantly, autophagy serves as an integral quality control mechanism by recycling cellular constituents for energy consumption and cellular rejuvenation under basal and stress conditions. Nevertheless, there is growing evidence that under certain conditions autophagy can switch from an adaptive survival mechanism to maladaptive process that promotes cell death. Furthermore, defects in autophagy have been linked to mitochondria injury and cell death associated with aging. In this review, we describe the role of autophagy as a physiological mechanism for maintaining homeostasis with its specific involvement in mitochondrial quality control and cardiac aging.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Cardiovascular Medicine - Volume 28, Issue 4, May 2018, Pages 246-260
نویسندگان
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