کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8681022 | 1579503 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual autonomic inhibitory action of central Apelin on gastric motor functions in rats
ترجمه فارسی عنوان
دوپارگی مهاری اپئون مرکزی در عملکرد حرکتی معده در موش صحرایی
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کلمات کلیدی
آپین، تخلیه معده، تحرک معده، سامانه ی عصبی خودمختار،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Centrally administered apelin has been shown to inhibit gastric emptying (GE) in rodents, however, the relevant mechanism has been investigated incompletely. Using male Wistar rats, we investigated the efferent pathways involved in gastroinhibitory action of central apelin. Stereotaxic intracerebroventricular (icv) cannulation, subdiaphragmatic vagotomy (VGX) and/or celiac ganglionectomy (CGX) were performed 7â¯days prior to the experiments. Apelin-13 was administered (30â¯nmol, icv) 90â¯min prior to GE measurement. Nitric oxide synthase inhibitor L-NAME (100â¯mg/kg), sympatholytic agent guanethidine (5â¯mg/kg) and/or muscarinic receptor agonist bethanechol (1â¯mg/kg) were administered intraperitoneally 30â¯min prior to the central apelin-13 injection. Two strain gages were implanted serosally onto antrum and pylorus to monitor gastric postprandial motility. Heart rate variability (HRV) analysis was performed before and after central vehicle or apelin-13 administration. Apelin-13 delayed solid GE significantly by disturbing coordinated antral and pyloric postprandial contractions. The apelin-induced delayed GE was attenuated partially by CGX or VGX, whereas it was restored completely in rats underwent both CGX and VGX. L-NAME did not change the apelin-induced alterations. Guanethidine or bethanechol restored the apelin-induced gastroinhibition partially, while it was abolished completely in rats received both agents. Apelin-13 decreased the HRV spectral activity in high-frequency range by increasing low-frequency component and the ratio of LF:HF. The present data suggest that (1) both vagal parasympathetic and sympathetic pathways play a role in apelin-induced gastroinhibition, (2) central apelin attenuates vagal cholinergic pathway rather than activating nonadrenergic-noncholinergic pathway. Apelin/APJ receptor system might be candidate for the treatment of autonomic dysfunction and gastrointestinal motor disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 212, July 2018, Pages 17-22
Journal: Autonomic Neuroscience - Volume 212, July 2018, Pages 17-22
نویسندگان
Mehmet Bülbül, Osman Sinen,