کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
868612 909810 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Reading microdots of a molecularly imprinted polymer by surface-enhanced Raman spectroscopy
چکیده انگلیسی

Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6–12 μm in diameter. The monitoring of SERS spectra with a micro-Raman system enabled examining the uptake and release of the S-propranolol imprinting template and allowed imaging individual dots as well as multiple dots in an array, revealing the distribution of the imprinted polymer. This distribution was confirmed by atomic force microscopy, showing that even in dots of <300 nm thickness, corresponding to MIP volumes of 0.5 fl, significantly less than previously reported, the target analyte could be detected and identified. This study shows that nanolithography techniques combined with SERS might open the possibility of miniaturized arrayed MIP sensors with label-free, specific and quantitative detection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 26, Issue 2, 15 October 2010, Pages 809–814
نویسندگان
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