کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8686820 1580834 2018 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modelling dynamic changes in blood flow and volume in the cerebral vasculature
ترجمه فارسی عنوان
مدلسازی تغییرات پویا در جریان خون و حجم خون در عروق مغزی
کلمات کلیدی
جریان خون مغزی، حجم خون مغزی، متابولیسم، چند منظوره،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
چکیده انگلیسی
We thus consider here the governing equations and some of the simplifications that have been proposed in order more rigorously to justify in what generations of blood vessels these approximations are valid. We show that two approximations (neglecting the advection term and assuming a quasi-steady state solution for blood volume) can be applied throughout the cerebral vasculature and that two further approximations (a simple first order differential relationship between inlet and outlet flows and inlet and outlet pressures, and matching of static pressure at nodes) can be applied in vessels smaller than approximately 1 mm in diameter. We then show how these results can be applied in solving flow fields within cerebral vascular networks providing a simplified yet rigorous approach to solving dynamic flow fields and compare the results to those obtained with alternative approaches. We thus provide a framework to model cerebral blood flow and volume within the cerebral vasculature that can be used, particularly at sub human imaging length scales, to provide greater insight into the behaviour of blood flow and volume in the cerebral vasculature.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 176, 1 August 2018, Pages 124-137
نویسندگان
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