کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8686839 | 1580834 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural and functional connectivity of the nondecussating dentato-rubro-thalamic tract
ترجمه فارسی عنوان
اتصال ساختاری و عملکردی از دنتاتو-روبرو-تالاموس غیرقابل انسداد
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کلمات کلیدی
DBSFEATFSLMNIBOLDSCPHCPFDRFunctional connectivity - اتصال عملکردی structural connectivity - ارتباط ساختاریsuperior cerebellar peduncle - اسب سواری مخچه بزرگMRI - امآرآی یا تصویرسازی تشدید مغناطیسیblood oxygenation level-dependent - اکسیژن خون وابسته به سطحThalamus - تالاموسdeep-brain stimulation - تحریک مغزی عمیقTractography - تراکتوگرافی Magnetic resonance imaging - تصویربرداری رزونانس مغناطیسیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیfMRI - تصویرسازی تشدید مغناطیسی کارکردیCerebellum - مخچهMontreal Neurological Institute - موسسه عصبی مونترالfalse discovery rate - میزان کشف کاذبfractional anisotropy - ناپیوستگی کسریHuman Connectome Project - پروژه اتصال انسانیFMRIB Software Library - کتابخانه نرم افزار FMRIB
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
The dentato-rubro-thalamic tract (DRTT) regulates motor control, connecting the cerebellum to the thalamus. This tract is modulated by deep-brain stimulation in the surgical treatment of medically refractory tremor, especially in essential tremor, where high-frequency stimulation of the thalamus can improve symptoms. The DRTT is classically described as a decussating pathway, ascending to the contralateral thalamus. However, the existence of a nondecussating (i.e. ipsilateral) DRTT in humans was recently demonstrated, and these tracts are arranged in distinct regions of the superior cerebellar peduncle. We hypothesized that the ipsilateral DRTT is connected to specific thalamic nuclei and therefore may have unique functional relevance. The goals of this study were to confirm the presence of the decussating and nondecussating DRTT pathways, identify thalamic termination zones of each tract, and compare whether structural connectivity findings agree with functional connectivity. Diffusion-weighted imaging was used to perform probabilistic tractography of the decussating and nondecussating DRTT in young healthy subjects from the Human Connectome Project (nâ¯=â¯91) scanned using multi-shell diffusion-weighted imaging (270 directions; TR/TEâ¯=â¯5500/89â¯ms; spatial resolutionâ¯=â¯1.25â¯mm isotropic). To define thalamic anatomical landmarks, a segmentation procedure based on the Morel Atlas was employed, and DRTT targeting was quantified based on the proportion of streamlines arriving at each nucleus. In parallel, functional connectivity analysis was performed using resting-state functional MRI (TR/TEâ¯=â¯720/33â¯ms; spatial resolutionâ¯=â¯2â¯mm isotropic). It was found that the decussating and nondecussating DRTTs have significantly different thalamic endpoints, with the former preferentially targeting relatively anterior and lateral thalamic nuclei, and the latter connected to more posterior and medial nuclei (pâ¯<â¯0.001). Functional and structural connectivity measures were found to be significantly correlated (râ¯=â¯0.45, pâ¯=â¯0.031). These findings provide new insight into pathways through which unilateral cerebellum can exert bilateral influence on movement and raise questions about the functional implications of ipsilateral cerebellar efferents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 176, 1 August 2018, Pages 364-371
Journal: NeuroImage - Volume 176, 1 August 2018, Pages 364-371
نویسندگان
Kalen J. Petersen, Jacqueline A. Reid, Srijata Chakravorti, Meher R. Juttukonda, Giulia Franco, Paula Trujillo, Adam J. Stark, Benoit M. Dawant, Manus J. Donahue, Daniel O. Claassen,