کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8688308 1580951 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson's disease
ترجمه فارسی عنوان
بررسی ارتباط اتصال استریاتایگرل با استفاده از روش تراکم احتمالی در بیماری پارکینسون
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی
Mean putamen-SN streamline density was lower in PD on both sides of the brain and in both 40- and 60-direction data. The optimized sequence provided a greater separation between PD and control means; however, individual values overlapped between groups. The 60-direction data also yielded mean connection probability values either trending (ipsilateral) or significantly (contralateral) lower in the PD group. There were minor between-group differences in average diffusion measures within the substantia nigra ROIs that did not affect the results of the GLM analyses when included as covariates. Based on these results, we conclude that mean striatonigral structural connectivity differs between PD and control groups and that use of an optimized 60-direction DWI sequence with overlapping slices increases the sensitivity of the technique to putative disease-related differences. However, overlap in individual values between disease groups limits its use as a classifier.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 16, 2017, Pages 557-563
نویسندگان
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