کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8688661 | 1580953 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered structural brain changes and neurocognitive performance in pediatric HIV
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کلمات کلیدی
FSPGRNeurocognitive functionsGATTBMFOVROIs - ROI هاstructural connectivity - ارتباط ساختاریFLAIR - اشتباهMRI - امآرآی یا تصویرسازی تشدید مغناطیسیAIDS - ایدزfluid attenuation inversion recovery - بازیابی معکوس کاهش مایعTensor based morphometry - تانسور بر اساس مورفومتریEnzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیSubcortical volume - حجم زیرکوهیecho time - زمان اکوRepetition time - زمان تکرارacquired immunodeficiency syndrome - سندرم نقص ایمنی به دست آوردcortical thickness - ضخامت قشرClustering coefficient - ضریب خوشه بندیCharacteristic path length - طول مسیر مشخص شدهRegions Of Interest - مناطق مورد علاقهField of view - میدان دیدhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Pediatric HIV patients often suffer with neurodevelopmental delay and subsequently cognitive impairment. While tissue injury in cortical and subcortical regions in the brain of adult HIV patients has been well reported there is sparse knowledge about these changes in perinatally HIV infected pediatric patients. We analyzed cortical thickness, subcortical volume, structural connectivity, and neurocognitive functions in pediatric HIV patients and compared with those of pediatric healthy controls. With informed consent, 34 perinatally infected pediatric HIV patients and 32 age and gender matched pediatric healthy controls underwent neurocognitive assessment and brain magnetic resonance imaging (MRI) on a 3Â T clinical scanner. Altered cortical thickness, subcortical volumes, and abnormal neuropsychological test scores were observed in pediatric HIV patients. The structural network connectivity analysis depicted lower connection strengths, lower clustering coefficients, and higher path length in pediatric HIV patients than healthy controls. The network betweenness and network hubs in cortico-limbic regions were distorted in pediatric HIV patients. The findings suggest that altered cortical and subcortical structures and regional brain connectivity in pediatric HIV patients may contribute to deficits in their neurocognitive functions. Further, longitudinal studies are required for better understanding of the effect of HIV pathogenesis on brain structural changes throughout the brain development process under standard ART treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 14, 2017, Pages 316-322
Journal: NeuroImage: Clinical - Volume 14, 2017, Pages 316-322
نویسندگان
Santosh K. Yadav, Rakesh K. Gupta, Ravindra K. Garg, Vimala Venkatesh, Pradeep K. Gupta, Alok K. Singh, Sheema Hashem, Asma Al-Sulaiti, Deepak Kaura, Ena Wang, Francesco M. Marincola, Mohammad Haris,