کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8688766 | 1580953 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy
ترجمه فارسی عنوان
ضخامت قشر غیر طبیعی ناشی از اشعه در بیماران مبتلا به کارسینوم ناحیه بینی ناشی از پرتودرمانی
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کلمات کلیدی
preCGNPCKPSIPCCMBsSTCMTCDMNSBMVBMKarnofsky Performance Status ScaleFWHMbSTSICCGLMFDRIMRTAJCCStructural MRI - MRI ساختاریbrain injury - آسیب مغزیPrecuneus - احتیاطanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceRadiotherapy - رادیوتراپیPostcentral gyrus - زنجیرهای Postcentralsurface-based morphometry - سطح مورفومتریdefault mode network - شبکه حالت پیش فرضcortical thickness - ضخامت قشرfull width at half maximum - عرض کامل در نیمی از حداکثرlateral occipital cortex - قشر جانبی گوشه گوشه سمت چپSuperior temporal cortex - قشر فوقالعاده قارچ زمانیInferior parietal cortex - قشر نای پایین ترGray matter - ماده خاکستریwhite matter - ماده سفیدLoc - محلGeneral linear model - مدل خطی کلیvoxel-based morphometry - مورفومتری مبتنی بر واکسلfalse discovery rate - میزان کشف کاذبCerebral microbleeds - میکروب های مغزیintensity-modulated radiation therapy - پرتودرمانی شدید مدولاسیونNasopharyngeal carcinoma - کارسینوم نازوفارنکسAmerican Joint Committee on Cancer - کمیته مشترک آمریکا در مورد سرطانprecentral gyrus - گریش precentral
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Conventional MRI studies showed that radiation-induced brain necrosis in patients with nasopharyngeal carcinoma (NPC) in years after radiotherapy (RT) could involve brain gray matter (GM) and impair brain function. However, it is still unclear the radiation-induced brain morphological changes in NPC patients with normal-appearing GM in the early period after RT. In this study, we acquired high-resolution brain structural MRI data from three groups of patients, 22 before radiotherapy (pre-RT) NPC patients with newly diagnosed but not yet medically treated, 22 NPC patients in the early-delayed stage after radiotherapy (post-RT-ED), and 20 NPC patients in the late-delayed stage after radiotherapy (post-RT-LD), and then analyzed the radiation-induced cortical thickness alteration in NPC patients after RT. Using a vertex-wise surface-based morphometry (SBM) approach, we detected significantly decreased cortical thickness in the precentral gyrus (PreCG) in the post-RT-ED group compared to the pre-RT group. And the post-RT-LD group showed significantly increased cortical thickness in widespread brain regions, including the bilateral inferior parietal, left isthmus of the cingulate, left bank of the superior temporal sulcus and left lateral occipital regions, compared to the pre-RT group, and in the bilateral PreCG compared to the post-RT-ED group. Similar analysis with ROI-wise SBM method also found the consistent results. These results indicated that radiation-induced brain injury mainly occurred in the post-RT-LD group and the cortical thickness alterations after RT were dynamic in different periods. Our findings may reflect the pathogenesis of radiation-induced brain injury in NPC patients with normal-appearing GM and an early intervention is necessary for protecting GM during RT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 14, 2017, Pages 610-621
Journal: NeuroImage: Clinical - Volume 14, 2017, Pages 610-621
نویسندگان
Jiabao Lin, Xiaofei Lv, Meiqi Niu, Lizhi Liu, Jun Chen, Fei Xie, Miao Zhong, Shijun Qiu, Li Li, Ruiwang Huang,