کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8689047 | 1580955 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abnormal visuomotor processing in schizophrenia
ترجمه فارسی عنوان
پردازش عصبی غیرمعمول در اسکیزوفرنیا
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کلمات کلیدی
جنون جوانی، مغناطیس فوگلوگرافی، قشر مکرر، کورتکس ویژوال، فرآیندهای الکتروفیزیولوژیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Subtle disturbances of visual and motor function are known features of schizophrenia and can greatly impact quality of life; however, few studies investigate these abnormalities using simple visuomotor stimuli. In healthy people, electrophysiological data show that beta band oscillations in sensorimotor cortex decrease during movement execution (event-related beta desynchronisation (ERBD)), then increase above baseline for a short time after the movement (post-movement beta rebound (PMBR)); whilst in visual cortex, gamma oscillations are increased throughout stimulus presentation. In this study, we used a self-paced visuomotor paradigm and magnetoencephalography (MEG) to contrast these responses in patients with schizophrenia and control volunteers. We found significant reductions in the peak-to-peak change in amplitude from ERBD to PMBR in schizophrenia compared with controls. This effect was strongest in patients who made fewer movements, whereas beta was not modulated by movement in controls. There was no significant difference in the amplitude of visual gamma between patients and controls. These data demonstrate that clear abnormalities in basic sensorimotor processing in schizophrenia can be observed using a very simple MEG paradigm.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage: Clinical - Volume 12, February 2016, Pages 869-878
Journal: NeuroImage: Clinical - Volume 12, February 2016, Pages 869-878
نویسندگان
Siân E. Robson, Matthew J. Brookes, Emma L. Hall, Lena Palaniyappan, Jyothika Kumar, Michael Skelton, Nikolaos G. Christodoulou, Ayaz Qureshi, Fiesal Jan, Mohammad Z. Katshu, Elizabeth B. Liddle, Peter F. Liddle, Peter G. Morris,