کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
870107 | 909851 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Integrated electrodes on a silicon based ion channel measurement platform
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Integrated electrodes on a silicon based ion channel measurement platform Integrated electrodes on a silicon based ion channel measurement platform](/preview/png/870107.png)
چکیده انگلیسی
We demonstrate the microfabrication of a low-noise silicon based device with integrated silver/silver chloride electrodes used for the measurement of single ion channel proteins. An aperture of 150 μm diameter was etched in a silicon substrate using a deep silicon reactive ion etcher and passivated with 30 nm of polytetrafluoroethylene via chemical vapor deposition. The average recorded noise in measurements of lipid bilayers was reduced by a factor of four through patterning of a 75 μm thick SU-8 layer around the aperture. Integrated electrodes were fabricated on both sides of the device and used for repeatable, stable, giga-seal bilayer formations as well as characteristic measurements of the transmembrane protein OmpF porin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biosensors and Bioelectronics - Volume 23, Issue 2, 30 September 2007, Pages 183–190
Journal: Biosensors and Bioelectronics - Volume 23, Issue 2, 30 September 2007, Pages 183–190
نویسندگان
S.J. Wilk, L. Petrossian, M. Goryll, T.J. Thornton, S.M. Goodnick, J.M. Tang, R.S. Eisenberg,