کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8720378 | 1589288 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Topical vancomycin and its effect on survival and migration of osteoblasts, fibroblasts, and myoblasts: An in vitro study
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب اورژانس
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The purpose of this study was to examine the influence of topical vancomycin on cell migration and survival of tissue healing cells. Human osteoblasts, myoblasts and fibroblasts were exposed to vancomycin at concentrations of 1, 3, 6, or 12â¯mg/cm2 for either a 1-h or 48-h (continuous) duration. Continuous exposure to all vancomycin concentrations significantly reduced cell survival (<22% cells survived) and migration in osteoblasts and myoblasts (Pâ¯<â¯0.001). 1-h vancomycin exposure reduced osteoblast and myoblast survival and migration only at 12â¯mg/cm2 (Pâ¯<â¯0.001). Further in vivo studies are warranted to optimize the dosage of intrawound vancomycin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedics - Volume 15, Issue 1, March 2018, Pages 53-58
Journal: Journal of Orthopaedics - Volume 15, Issue 1, March 2018, Pages 53-58
نویسندگان
James X. Liu, Dalibel Bravo, John Buza, Thorsten Kirsch, Oran Kennedy, Andrew Rokito, Joseph D. Zuckerman, Mandeep S. Virk,