کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8722456 | 1589456 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Screening, prophylaxis and counselling before the start of biological therapies: A practical approach focused on IBD patients
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The standard of care in the management of immune-mediated inflammatory conditions relies on immunomodulators, glucocorticoids, and biologicals (including anti-tumour necrosis factor âα and other monoclonal antibodies). These agents have an overall favourable benefit/risk ratio; however, they modulate the immune response as part of their mechanisms of action, and therefore they may increase the risk of developing infections, particularly in older patients or in patients with concomitant corticosteroids. Some of these infections may be preventable by immunization, chemoprophylaxis or counselling. AIM: screening for and monitoring infections throughout these therapies is so mandatory to ensure patients' safety. Still, standardized guidelines focused on these procedures have yet to be established. This review aims to fill such a gap. The authors searched for articles published in English from 2009 until 2017 using PUBMED, with the terms “immunomodulators”, “biological drugs”, “anti-TNF α”, “inflammatory bowel diseases”, “immunomediated inflammatory diseases”, “risk of infection”, “infection prevention”, “screening”, “immunization”, “tuberculosis”, “latent tuberculosis”, “listeriosis”, “endemic mycosis”, “Pneumocystis jiroveci pneumonia”, “granulomatous infection”, “varicella”, “herpes virus”, “hepatitis B”, “hepatitis A”, “hepatitis C” and identified the journal articles. Based on the literature and in their own experience the authors established recommendations and a practical guide for infections' screening, monitoring and prevention before and during immunomodulatory and biological therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 49, Issue 12, December 2017, Pages 1289-1297
Journal: Digestive and Liver Disease - Volume 49, Issue 12, December 2017, Pages 1289-1297
نویسندگان
Cândida Abreu, António Sarmento, Fernando Magro,