کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8724416 | 1589710 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Métodos de tiroglobulina de primera y segunda generación: su utilidad en pacientes con cáncer diferenciado de tiroides
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کلمات کلیدی
Anticuerpos antitiroglobulinaImmunoassays - آزمایشات ایمنیAnti-thyroglobulin antibodies - آنتیبادیهای ضد تیروئروگلوبولینInmunoanálisis - ایمونوآنتیDifferentiated thyroid cancer - تشخیص سرطان تیروئیدCancer diferenciado de tiroides - تشخیص سرطان تیروئیدThyroglobulin - تیروگلوبولینTiroglobulina - تیروگلوبولینInterferences - موانعInterferencias - موانع
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
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![عکس صفحه اول مقاله: Métodos de tiroglobulina de primera y segunda generación: su utilidad en pacientes con cáncer diferenciado de tiroides Métodos de tiroglobulina de primera y segunda generación: su utilidad en pacientes con cáncer diferenciado de tiroides](/preview/png/8724416.png)
چکیده انگلیسی
Differentiated thyroid cancer (DTC) is the most common endocrine cancer (tumour) and its incidence has risen in the past decades. Its follow-up includes measuring serum thyroglobulin (Tg), performing neck ultrasound and a diagnostic whole-body scan. Tg assays have evolved with time. At present immunoassays for Tg are classified as 1Â st and 2Â nd generation assays (1Â st G and 2Â nd G). 2Â nd G assays show an adequate (good) precision at levels close to 0.1Â ng/ml and 1Â st G assays at levels close to 1Â ng/ml. The literature shows that for low risk patients on levothyroxine treatment, who undetectable levels by 2Â ªG assays can avoid the stimulation test performed by thyroid hormone withdrawal or after recombinant human TSH, due to better sensitivity. However, due to lower specificity, detectable levels do not confirm the presence of disease (tumour), and should be confirmed. To optimise the clinical usefulness of the test, cut-off values specific for population and method should be used, instead of functional sensitivity or quantification limit. Critical issues for measuring Tg are discussed, such as non-harmonisation of methods, and interferences, mainly by anti-thyroglobulin antibodies (ATg). 1Â st and 2Â nd G assays are less useful in presence of ATg, and follow up of such patients is limited. Consensus between physicians and the laboratory on technical issues and interpretation criteria of Tg values is of outmost importance in the follow-up of DTC patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Argentina de EndocrinologÃa y Metabolismo - Volume 54, Issue 3, JulyâSeptember 2017, Pages 101-108
Journal: Revista Argentina de EndocrinologÃa y Metabolismo - Volume 54, Issue 3, JulyâSeptember 2017, Pages 101-108
نویسندگان
Isabel Teres, Graciela Astarita, Viviana Mesch, Graciela Mosquera Filoso, MarÃa Paula Esteban, Andrea Kozac, Natalia Blanco Hirota, Mirta Gurfinkiel, Ana MarÃa Sequera, Patricia Pagano, Mónica Saavedra, MarÃa José Iparraguirre, Marta Torres,