کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8724458 1589714 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detección y caracterización de autoanticuerpos anti-ZnT8 en pacientes argentinos con diabetes mellitus tipo 1
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Detección y caracterización de autoanticuerpos anti-ZnT8 en pacientes argentinos con diabetes mellitus tipo 1
چکیده انگلیسی
Immunochemical characterisation of ZnT8A present in type 1 Argentinian diabetic patients was accomplished, employing different variants of ZnT8. An increased detection of autoimmunity was found when ZnT8A was employed in combination with the other islet-autoantibodies. The presence of autoantibodies that recognized only constructions containing Arg reveals the existence of epitopes dependent of the amino acid present at residue 325. Furthermore, application of dimeric constructions revealed the existence of quaternary structure-defined epitopes which were recognized by type 1 diabetic patients. Finally, the highest combined sensitivity and specificity for routine screening of ZnT8A was accomplished with the heterodimeric construction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revista Argentina de Endocrinología y Metabolismo - Volume 53, Issue 3, July–September 2016, Pages 77-83
نویسندگان
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