کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8726614 1590028 2018 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lamins and Lamin-Associated Proteins in Gastrointestinal Health and Disease
ترجمه فارسی عنوان
لامین ها و پروتئین های مرتبط با لامین در سلامت و بیماری های دستگاه گوارش
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی
The nuclear lamina is a multi-protein lattice composed of A- and B-type lamins and their associated proteins. This protein lattice associates with heterochromatin and integral inner nuclear membrane proteins, providing links among the genome, nucleoskeleton, and cytoskeleton. In the 1990s, mutations in EMD and LMNA were linked to Emery-Dreifuss muscular dystrophy. Since then, the number of diseases attributed to nuclear lamina defects, including laminopathies and other disorders, has increased to include more than 20 distinct genetic syndromes. Studies of patients and mouse genetic models have pointed to important roles for lamins and their associated proteins in the function of gastrointestinal organs, including liver and pancreas. We review the interactions and functions of the lamina in relation to the nuclear envelope and genome, the ways in which its dysfunction is thought to contribute to human disease, and possible avenues for targeted therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 154, Issue 6, May 2018, Pages 1602-1619.e1
نویسندگان
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