Keywords: مهارکننده Farnesyl Transferase; Nucleoskeleton; Envelopathies; Progeria; Myopathy; Neuropathy; Lipodystrophy; Nonalcoholic Fatty Liver Disease; BANF1; barrier to autointegration factor; EDMD; Emery-Dreifuss muscular dystrophy; FTI; farnesyl transferase inhibitor; FPLD2; type 2 (Dunnigan
مقالات ISI مهارکننده Farnesyl Transferase (ترجمه نشده)
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Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons
Keywords: مهارکننده Farnesyl Transferase; Simvastatin; Hippocampus; NMDA receptors; Farnesyl-pyrophosphate (FPP); Histone acetylation of GluN2B; Src; α7nAChR; α7 nicotinic acetylcholine receptor; AD; Alzheimer's disease; Aβ; β-amyloid peptides; ACSF; artificial cerebral spinal fluid; AHP; aft
Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells
Keywords: مهارکننده Farnesyl Transferase; Influenza A virus; Sterol biosynthesis; Farnesyl transferase inhibitor; Statin; Zometa; Cytokine;
Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: Protection by nifedipine
Keywords: مهارکننده Farnesyl Transferase; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; FTase; farnesyl transferase; FTI; farnesyl transferase inhibitor; Nif; nifedipine; PBA; 4-phenylbutyric acid; Tg; thapsigargin; Caspase 3; Glucotoxicity; Nuclear lamin B; Pancreatic islet β-cell;
Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities
Keywords: مهارکننده Farnesyl Transferase; Farnesyl transferase inhibitor; Preclinical hepatic metabolism; Drug-drug interaction; Cytochrome P450;
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
Keywords: مهارکننده Farnesyl Transferase; statins; isoprenoids; protein prenylation; synaptic plasticity; hippocampus; long-term potentiation; aCSF; artificial cerebral spinal fluid; AD; Alzheimer's disease; Akt; protein kinase B; fEPSPs; field excitatory postsynaptic potentials; FPP; farnesyl py
Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP)
Keywords: مهارکننده Farnesyl Transferase; DDO; double drop-out; FTI; farnesyl transferase inhibitor; GPCR; G protein-coupled receptor; HA; hemagglutinin; hIP; human prostacyclin receptor; HUVEC; human umbilical vein endothelial cell; IKEPP; intestinal and kidney enriched PDZ protein; IP; prostacy
The enhanced host-cell permissiveness of human cytomegalovirus is mediated by the Ras signaling pathway
Keywords: مهارکننده Farnesyl Transferase; DMEM; Dulbecco's Modified Eagle's Medium; E; Early; EBV; Epstein-Barr virus; EGF; Epidermal Growth Factor; EGFR; Epidermal Growth Factor Receptor; ERK; Extracellular Regulated Kinase; FBS; Fetal Bovine Serum; FTI; Farnesyl Transferase Inhibitor; HFF; Huma
In vivo apoptosis detection with radioiodinated Annexin V in LoVo tumour-bearing mice following Tipifarnib (Zarnestra, R115777) farnesyltransferase inhibitor therapy
Keywords: مهارکننده Farnesyl Transferase; Annexin V; Apoptosis; Farnesyl transferase inhibitor; Oncology; Tipifarnib;
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NFκB ligand (RANKL) or tumor necrosis factor-α (TNF-α)
Keywords: مهارکننده Farnesyl Transferase; pOC; preosteoclast; RANKL; receptor activator of NFκB ligand; M-CSF; macrophage colony-stimulating factor; GGTI; geranylgeranyl transferase inhibitor; GGOH; geranylgeraniol; FTI; farnesyl transferase inhibitor; TRAP; tartrate-resistant acid phosphatase;
Statins potentiate the IFN-γ-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells
Keywords: مهارکننده Farnesyl Transferase; C/EBP-β; CAAT-enhancer-binding protein-β; cPLA2; cytosolic phospholipase A2; DRB; 5,6-Dichloro-1-β-d-ribofuranosylbenzimidazole; ELISA; enzyme linked immunosorbent assay; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; FPP; farnesyl