Interaction of the human prostacyclin receptor and the NHERF4 family member intestinal and kidney enriched PDZ protein (IKEPP)

► Prostacyclin plays a central role in hemostasis and vascular re-endothelialization. ► IKEPP was discovered as a direct functional interactant of the prostacyclin receptor. ► We provide the first evidence that IKEPP is expressed in the vascular endothelium. ► IKEPP co-localizes and is associated with the hIP in vascular endothelial cells. ► IKEPP regulates prostacyclin-induced endothelial migration and in vitro angiogenesis.