Identification of a small molecule inhibitor of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] using mixture-based combinatorial libraries

- Inhibitors of resistance enzymes can extend the life of existing aminoglycosides.
- Identification of novel inhibitors using mixture-based combinatorial libraries.
- A substituted pyrrolidine pentamine significantly reduces resistance to amikacin.