کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8738624 | 1591731 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urinary concentrations and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption
ترجمه فارسی عنوان
غلظت ادرار و فعالیت ضد میکروبی توبرامایسین در داوطلبان سالم که یک دوز خوراکی یک فرمول جدید برای جذب بهتر را دریافت می کنند
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Oral antibiotics for the treatment of urinary tract infections are scarce. In this ex vivo phase 1 annex study, the clinical safety, urinary concentrations and bactericidal activity of a new formulation for improved oral absorption of tobramycin (Tobrateâ¢) were evaluated. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of five test strains, one reference strain and four clinical uropathogenic strains were determined in cation-adjusted Mueller-Hinton broth (CA-MHB) and in pooled antimicrobial agent-free subjects' urine at different pH values (5.5, 6.5, 7.5 and 8.5). Urinary concentrations and urinary bactericidal titres (UBTs) following single oral administration of 600âmg Tobrate⢠were measured in nine healthy volunteers up to 24âh. The MIC/MBC values in CA-MHB were 2-4/2-4âmg/L for two Escherichia coli strains, 2/2âmg/L for Klebsiella pneumoniae, 0.5/1âmg/L for Pseudomonas aeruginosa and 8/1âmg/L for Proteus mirabilis. MBCs in pooled alkaline urine were significantly lower than those in acidic urine. The mean maximum urinary concentration following 600âmg tobramycin was 83.9âmg/L (2-4âh collection period). The highest reciprocal median UBT values for each test strain were between 2 and 4 during the collection periods 2-4âh and 4-8âh, respectively. The new enteric oral tobramycin formulation significantly improved the very poor oral absorption of standard tobramycin salt. For all pathogens tested, maximum urinary concentrations of tobramycin were at least two times above the urinary MBC. A twice- or three-times daily dosage regimen and alkalising co-medication may further improve urinary bactericidal activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 51, Issue 3, March 2018, Pages 422-426
Journal: International Journal of Antimicrobial Agents - Volume 51, Issue 3, March 2018, Pages 422-426
نویسندگان
Maria Loose, Kurt G. Naber, Paul Shields, Harald Reinhart, Florian M.E. Wagenlehner,