کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8740686 | 1592424 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chemotherapy for alpha-fetoprotein producing gastric cancers expressing human epidermal growth factor receptor 2
ترجمه فارسی عنوان
شیمیدرمانی برای تولید سرطان معده تولید آلفا فتوپروتئین که گیرنده 2 فاکتور رشد اپیدرمی انسان است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Although, gastric cancer is one of the most common cancers worldwide, alpha-fetoprotein (AFP) producing human epidermal growth factor receptor 2 (HER2) positive gastric cancers are rare. AFP producing gastric cancer has a poor prognosis and an appropriate treatment option has not been established to date. A 75-year-old woman with AFP- producing gastric cancer was treated with S-1, an oral fluoropyrimidine derivative, chemotherapy after distal gastrectomy. Recurrence of gastric cancer was observed after 18 months and immunohistochemistry analysis showed AFP and HER2 positive gastric cancer. The patient received combination therapy containing capecitabine, cisplatin, and trastuzumab. Computed tomography scans showed regression of the lymph node metastasis. The patient's quality of life substantially improved after the treatment. Thus, the present case suggests that AFP and HER2 positive gastric cancer can be effectively treated with, capecitabine, cisplatin, and trastuzumab combination therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Infection and Chemotherapy - Volume 24, Issue 4, April 2018, Pages 298-301
Journal: Journal of Infection and Chemotherapy - Volume 24, Issue 4, April 2018, Pages 298-301
نویسندگان
Kazumi Hayashi, Eijiro Nagasaki, Koji Nakada, Miho Tamura, Yasuhiro Arakawa, Tadashi Uwagawa, Shingo Yano,