کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8740989 1592439 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria
ترجمه فارسی عنوان
پپتید های ضد میکروبی به عنوان عوامل ضد بیوفیلم بالقوه در مقابل باکتری های مقاوم به چندین دارو
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Bacterial resistance to commonly used drugs has become a global health problem, causing increased infection cases and mortality rate. One of the main virulence determinants in many bacterial infections is biofilm formation, which significantly increases bacterial resistance to antibiotics and innate host defence. In the search to address the chronic infections caused by biofilms, antimicrobial peptides (AMP) have been considered as potential alternative agents to conventional antibiotics. Although AMPs are commonly considered as the primitive mechanism of immunity and has been extensively studied in insects and non-vertebrate organisms, there is now increasing evidence that AMPs also play a crucial role in human immunity. AMPs have exhibited broad-spectrum activity against many strains of Gram-positive and Gram-negative bacteria, including drug-resistant strains, and fungi. In addition, AMPs also showed synergy with classical antibiotics, neutralize toxins and are active in animal models. In this review, the important mechanisms of action and potential of AMPs in the eradication of biofilm formation in multidrug-resistant pathogen, with the goal of designing novel antimicrobial therapeutics, are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Microbiology, Immunology and Infection - Volume 50, Issue 4, August 2017, Pages 405-410
نویسندگان
, ,