Baseline resistance and cross-resistance among fluoroquinolones in multidrug-resistant Mycobacterium tuberculosis isolates at a national reference laboratory in India

A huge proportion of MDR-TB strains (32%) exhibiting OFX resistance prior to treatment with second-line anti-TB drugs raises major concern. Detection of baseline drug resistance in TB patients helps in reducing the transmission of drug-resistant TB. The OFX MIC was higher than its critical concentration, indicating the prevalence of baseline resistance to FQs owing to irrational use of these drugs.