کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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876454 | 910845 | 2012 | 8 صفحه PDF | دانلود رایگان |
Needle-free drug delivery by jet injection is achieved by ejecting a liquid drug through a narrow orifice at high pressure, thereby creating a fine high-speed fluid jet that can readily penetrate skin and tissue. Until very recently, all jet injectors utilized force- and pressure-generating principles that progress injection in an uncontrolled manner with limited ability to regulate delivery volume and injection depth. In order to address these shortcomings, we have developed a controllable jet injection device, based on a custom high-stroke linear Lorentz-force motor that is feed-back controlled during the time-course of an injection.Using this device, we are able to monitor and modulate continuously the speed of the drug jet, and regulate precisely the volume of drug delivered during the injection process. We demonstrate our ability to control injection depth (up to 16 mm) and repeatably and precisely inject volumes of up to 250 μL into transparent gels and post-mortem animal tissue.
Journal: Medical Engineering & Physics - Volume 34, Issue 9, November 2012, Pages 1228–1235