کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8768487 1597880 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing
چکیده انگلیسی
DA closure is crucial for the transition from fetal to neonatal life. This closure is supported by changes to the DA's signaling and structural properties that distinguish it from neighboring vessels. Examining transcriptional differences between these vessels is key to identifying genes or pathways responsible for DA closure. Several microarray studies have explored the DA transcriptome in animal models but varied experimental designs have led to conflicting results. Thorough transcriptomic analysis of the human DA has yet to be performed. A clear picture of the DA transcriptome is key to guiding future research endeavors, both to allow more targeted treatments in the clinical setting, and to understand the basic biology of DA function. In this review, we use a cross-species cross-platform analysis to consider all available published rodent microarray data and novel human RNAseq data in order to provide high priority candidate genes for consideration in future DA studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Perinatology - Volume 42, Issue 4, June 2018, Pages 212-220
نویسندگان
, , , , , , , , , ,