کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
877326 910932 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of EEG background activity in Alzheimer's disease patients with Lempel–Ziv complexity and central tendency measure
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Analysis of EEG background activity in Alzheimer's disease patients with Lempel–Ziv complexity and central tendency measure
چکیده انگلیسی

In this study we have investigated the electroencephalogram (EEG) background activity in patients with Alzheimer's disease (AD) using non-linear analysis methods. We calculated the Lempel–Ziv (LZ) complexity – applying two different sequence conversion methods – and the central tendency measure (CTM) of the EEG in 11 AD patients and 11 age-matched control subjects. CTM quantifies the degree of variability, while LZ complexity reflects the arising rate of new patterns along with the EEG time series. We did not find significant differences between AD patients and control subjects’ EEGs with CTM. On the other hand, AD patients had significantly lower LZ complexity values (p < 0.01) at electrodes P3 and O1 with a two-symbol sequence conversion, and P3, P4, O1 and T5 using three symbols. Our results show a decreased complexity of EEG patterns in AD patients. In addition, we obtained 90.9% sensitivity and 72.7% specificity at O1, and 72.7% sensitivity and 90.9% specificity at P3 and P4. These findings suggest that LZ complexity may contribute to increase the insight into brain dysfunction in AD in ways which are not possible with more classical and conventional statistical methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Engineering & Physics - Volume 28, Issue 4, May 2006, Pages 315–322
نویسندگان
, , , , ,