Nanostructured SBA-15 silica: An effective protective vehicle to oral hepatitis B vaccine immunization

After proper oral immunization schedules using SBA-15 as adjuvant, the recruitment of inflammatory cells to Peyer's patches and mesenteric lymph nodes and the enhanced production of specific antibodies, as well as the non-influence of silica in the polarization to TH1 or TH2 immune responses, were shown.157