کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8774675 1599203 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insuficiencia cardíaca en la enfermedad renal y déficit de hierro: importancia de la ferroterapia
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Insuficiencia cardíaca en la enfermedad renal y déficit de hierro: importancia de la ferroterapia
چکیده انگلیسی
Chronic kidney disease and anaemia are common in heart failure (HF) and are associated with a worse prognosis in these patients. Iron deficiency is also common in patients with HF and increases the risk of morbidity and mortality, regardless of the presence or absence of anaemia. While the treatment of anaemia with erythropoiesis-stimulating agents in patients with HF have failed to show a benefit in terms of morbidity and mortality, treatment with IV iron in patients with HF and reduced ejection fraction and iron deficiency is associated with clinical improvement. In a posthoc analysis of a clinical trial, iron therapy improved kidney function in patients with HF and iron deficiency. In fact, the European Society of Cardiology's recent clinical guidelines on HF suggest that in symptomatic patients with reduced ejection fraction and iron deficiency, treatment with IV ferric carboxymaltose should be considered to improve symptoms, the ability to exercise and quality of life. Iron plays a key role in oxygen storage (myoglobin) and in energy metabolism, and there are pathophysiological bases that explain the beneficial effect of IV iron therapy in patients with HF. All these aspects are reviewed in this article.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nefrología - Volume 37, Issue 6, November–December 2017, Pages 587-591
نویسندگان
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