کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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877756 | 911044 | 2013 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Nanoliposomal minocycline for ocular drug delivery Nanoliposomal minocycline for ocular drug delivery](/preview/png/877756.png)
Nanoliposomal technology is a promising drug delivery system that could be employed to improve the pharmacokinetic properties of clearance and distribution in ocular drug delivery to the retina. We developed a nanoscale version of an anionic, cholesterol-fusing liposome that can encapsulate therapeutic levels of minocycline capable of drug delivery. We demonstrate that size extrusion followed by size-exclusion chromatography can form a stable 80-nm liposome that encapsulates minocycline at a concentration of 450 ± 30 μM, which is 2% to 3% of loading material. More importantly, these nontoxic nanoliposomes can then deliver 40% of encapsulated minocycline to the retina after a subconjunctival injection in the STZ model of diabetes. Efficacy of therapeutic drug delivery was assessed via transcriptomic and proteomic biomarker panels. For both the free minocycline and encapsulated minocycline treatments, proinflammatory markers of diabetes were downregulated at both the messenger RNA and protein levels, validating the utility of biomarker panels for the assessment of ocular drug delivery vehicles.From the Clinical EditorAuthors developed a nano-liposome that can encapsulate minocycline for optimized intraocular drug delivery. These nontoxic nanoliposomes delivered 40% of encapsulated minocycline to the retina after a subconjunctival injection in a diabetes model.
Graphical AbstractThe leading cause of preventable blindness among working-age adults in the industrialized world is diabetic retinopathy (DR). Currently, there is no drug approved by the FDA specifically for DR, though various anti-inflammatory drugs are often used off-label, with limited success. Delivery of these pharmaceuticals to the retina poses a significant hurdle that inhibits the full therapeutic potential of many drugs. The figure presented here shows the promise of nanoscale liposomal subconjunctival delivery systems to cross the tissues of the eye and deliver therapeutic doses of an anti-inflammatory drug, minocycline, directly to the retina in a model of DR.Figure optionsDownload high-quality image ( K)Download as PowerPoint slide
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 9, Issue 1, January 2013, Pages 130–140