کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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877782 | 911047 | 2012 | 4 صفحه PDF | دانلود رایگان |

Integrin-binding, Arg-Gly-Asp (RGD)–containing peptides are the most widely used agents to deliver drugs, nanoparticles, and imaging agents. Although in nature, several protein-mediated signal transduction events depend on RGD motifs, the potential of RGD-empowered materials in triggering undesired cell-signaling cascades has been neglected. Using an RGD-functionalized protein nanoparticle, we show here that the RGD motif acts as a powerful trophic factor, supporting extracellular signal–regulated kinase 1/2 (ERK1/2)–linked cell proliferation and partial differentiation of PC12 cells, a neuronlike model.From the Clinical EditorThis work focuses on RGD peptides, which are among the most commonly used tags for targeted drug delivery. They also promote protoneurite formation and expression of neuronal markers (MAP2) in model PC12 cells, which is an unexpected but relevant event in the functionalization of drugs and their nanocarriers.
Graphical AbstractRGD peptides are potent trophic factors.We describe here that RGD peptides, among the most used tags for targeted delivery of drugs and nanoparticles, promote protoneurite formation, p-ERK1/2–dependent cell division in absence of serum, and expression of neuronal markers (MAP2) in model PC12 cells. The trophic potential of RGD peptides is an unexpected event of critical relevance in the functionalization of drugs and their nanocarriers.Figure optionsDownload high-quality image (101 K)Download as PowerPoint slide
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 8, Issue 8, November 2012, Pages 1263–1266