کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8778 605 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging
چکیده انگلیسی

Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 30, Issue 36, December 2009, Pages 6947–6954
نویسندگان
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