Mitigation of endometriosis using regenerative cerium oxide nanoparticles

Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis.From the Clinical EditorFree radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future.

Graphical AbstractOxidative stress associated with pathogenesis of endometriosis. Herein we report cerium oxide nanoparticle, a novel antioxidant material, mitigate the endometrial lesions induced in mice model by decreasing oxidative stress, and inhibiting VEGF expression and angiogenesis.Figure optionsDownload high-quality image (117 K)Download as PowerPoint slide