کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8779164 | 1600020 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Prostate Cancer: An Update on Molecular Pathology with Clinical Implications
ترجمه فارسی عنوان
سرطان پروستات: به روز رسانی در مورد آسیب شناسی مولکولی با پیامدهای بالینی
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کلمات کلیدی
سرطان پروستات، ژنومیک، مولکولی، بیومارکرها، آسیب شناسی،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
چکیده انگلیسی
Recent advances in sequencing technologies, proteomics, and metabolomics have led to the identification of numerous molecular alterations across solid tumors including prostate cancer. The delineation of various genetic and epigenetic events involved in tumor progression have facilitated the development of novel diagnostic tests and the successful therapeutic targeting of key oncogenic events in prostate cancer. The most common genomic aberrations in prostate cancer include gene fusions, amplification, deletion, and mutations. In addition, up and down regulation of gene expression in critical cellular pathways is also at play. A series of long noncoding RNA expression changes have been also unveiled from transcriptome sequencing data. They play a regulatory role in prostate cancer and are promising diagnostic and potentially prognostic markers. In this review, we summarize recent advances in molecular pathology of prostate cancer and their emerging clinical utility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology Supplements - Volume 16, Issue 12, December 2017, Pages 253-271
Journal: European Urology Supplements - Volume 16, Issue 12, December 2017, Pages 253-271
نویسندگان
George J. Netto, Marie-Lisa Eich, Sooryanarayana Varambally,