کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8782861 | 1600687 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia
ترجمه فارسی عنوان
زیست شناسی ایمنی در دوران بارداری در خون محیطی می تواند پره اکلامپسی را پیش بینی کند
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EGFFOXP3MIPROChemolysis elevated liver enzymes and low plateletsmAbsRORCCcl11GM-CSFHELLPT-bet - تی شرط بندیforkhead box P3 - جعبه جعبه P3epidermal growth factor - عامل رشد اپیدرمیgranulocyte-macrophage colony-stimulating factor - عامل گرانولوسیت-ماکروفاژ colony-stimulating factorgranulocyte colony-stimulating factor - فاکتور تحریک کننده کلنی گرانولوسیتG-CSF - فاکتور محرک کُلونی گرانولوسیتMonoclonal antibodies - پادتنهای تَکتیرهmacrophage inflammatory protein - پروتئین التهابی ماکروفاژreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
We performed a prospective cohort study in 197 pregnant women. Peripheral blood was collected between 5 and 16 weeks of gestation. Intracellular cytokine analysis and immunophenotype were performed by flow-cytometry. Serum levels of cytokines and chemokines were analyzed by multiplex assay. 86 patients were eligible for the analysis and 10.5% (n = 9) developed preeclampsia. Patients with preeclampsia had significantly higher percentage of CD3+CD4+TNFα+ T helper (Th) 1 cells (45.4 ± 10.3 vs 37.1 ± 8.5, P = 0.032) and CD3+CD4+IL17+ Th 17 cells (2.4 ± 1.3 vs 1.6 ± 1.1, P = 0.029) when compared to those of patients without preeclampsia. CD3+CD4+CD25+CD127dim/â T regulatory cells (Treg) cells (5.7 ± 1.2% vs 7.0 ± 1.6%, P = 0.015) were significantly lower in patients with preeclampsia when compared to those without preeclampsia. Patients with preeclampsia had significantly higher TNFα/IL-10 cell ratio (43.8 ± 10.3 vs 34.3 ± 7.9, P = 0.005) and Th17/Treg cell ratio (0.5 ± 0.3 vs 0.2 ± 0.2, P = 0.011) when compared to those of patients without preeclampsia. IL-8 and Macrophage inflammatory protein (MIP)-1α serum levels were significantly higher in patients with preeclampsia when compared with patients without preeclampsia (Median = 341.0 vs 87.6, U = 152, P = 0.020 and Median = 35.7 vs 17.7, U = 120, P = 0.029 respectively). Serum MCP-1 levels were significantly lower in patients with preeclampsia when compared with patients without preeclampsia (Median = 233.8 vs 390.9, U = 183, P = 0.021). The logistic regression predictive model combining TNFα/IL-10 ratios, IL-8 and MCP-1 serum levels had the best performance (AUC = 0.886, 95%CI 0.8-0.9). We concluded that elevated Th1 and Th17 cell percentages, elevated TNFα/IL-10 and Th17/Treg cell ratios and decreased Treg cell percentages in early pregnancy are associated with preeclampsia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Reproductive Immunology - Volume 125, February 2018, Pages 25-31
Journal: Journal of Reproductive Immunology - Volume 125, February 2018, Pages 25-31
نویسندگان
M.D. Salazar Garcia, Y. Mobley, J. Henson, M. Davies, A. Skariah, S. Dambaeva, A. Gilman-Sachs, K. Beaman, C. Lampley, J. Kwak-Kim,