کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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878315 | 911072 | 2009 | 8 صفحه PDF | دانلود رایگان |
In this study four types of SBAs were synthesized and then impregnated with hydrocortisone. One is a straight SBA-15, obtained using Pluronics P123 as structuring agent; two others were modified using 1,3,5-trimethylbenzene as additive, and the fourth one was prepared using sodium iodide as additive. Three of these have in common a p6mm symmetry with nanotubes packed hexagonally, yet they differ in their functional groups. The fourth sample is basically disordered. The drug release kinetics showed two stages: a fast-rate early stage dominated by the controlled release of the hydrocortisone adsorbed in the macropores of the reservoir, followed by a slow-rate delivery that we assume is controlled by the hydrocortisone diffusion through the nanopores. It is shown that the release kinetics can be strongly influenced by using different co-additives.
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 5, Issue 2, June 2009, Pages 170–177