کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8783298 | 1600752 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
No cytotoxic effects from application of pentoxifylline to spermatozoa on subsequent pre-implantation embryo development in mice
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: No cytotoxic effects from application of pentoxifylline to spermatozoa on subsequent pre-implantation embryo development in mice No cytotoxic effects from application of pentoxifylline to spermatozoa on subsequent pre-implantation embryo development in mice](/preview/png/8783298.png)
چکیده انگلیسی
The aim was to assess the effect of spermatozoa exposed to PTX on the rates of fertilization and embryo development and apoptotic cells within blastocysts in an animal model. Mice Oocytes were inseminated with spermatozoa exposed to 3.6 mmol PTX for 30 min, or with neat spermatozoa. Then fertilization and embryo development rate, blastocyst formation and quality, as well as total cell number of blastocyst, and DNA fragmentation index (DFI) in blastocysts were surveyed in both groups. Fertilization and embryo development rate were similar between the groups. The rates of blastocyst formation did not differ significantly between control and PTX groups (52.4% vs. 51.8%). The average of total cell count in blastocysts and DFI in control and PTX groups were also insignificant (31.08 ± 1.5 vs. 34.14 ± 1.5 and 9.76 ± 5.0 vs. 11.77 ± 5.4). Application of PTX for enhancing sperm motility does not cause a cytotoxic effect on subsequent embryo development and embryo genome integrity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Middle East Fertility Society Journal - Volume 22, Issue 2, June 2017, Pages 132-135
Journal: Middle East Fertility Society Journal - Volume 22, Issue 2, June 2017, Pages 132-135
نویسندگان
Mohammad Ali Khalili, Azam Agha-Rahimi, Fatemeh Sadeghian, Iman Halvaei,