کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
878334 | 911073 | 2008 | 11 صفحه PDF | دانلود رایگان |
Superparamagnetic nanoparticles have been synthesized that could potentially be used to magnetically target therapeutics within the body. The magnetic targeting and successful in-flow capture of 330-nm and 580-nm agglomerates of these magnetite nanoparticles was performed using a 0.5-T magnet. Optical observation of magnetic nanoparticle capture in microcapillary flow provides a useful preliminary way of establishing conditions for the magnetic capture of nanoparticles with direct relevance to blood vessels for magnetically directed therapy. A stable nanoparticle layer of 580-nm agglomerates could be formed at mean capillary flow velocities of up to 2.5 cm s–1 and for the 330-nm agglomerates at velocities up to 4.4 cm s–1. These data show that smaller nanoparticle agglomerates form a layer that is impervious to erosion by fluid shear. Capillary blocking by nanoparticles, analogous to an embolism, was not detected in these experiments.
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 4, Issue 1, March 2008, Pages 19–29