کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8791903 1602547 2018 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carnosic acid attenuates acrylamide-induced retinal toxicity in zebrafish embryos
ترجمه فارسی عنوان
اسید کارنوزیک سبب کاهش سمیت های شبکیه ناشی از آکریلامید در جنین های زرگری می شود
کلمات کلیدی
آکریلامید، اسید کارنوزیک، آسیب اکسیداتیو، شبکیه چشم، ماهی قزل آلا،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی
Acrylamide (ACR) is a water-soluble chemical used widely in industry, which can be formed in tobacco smoke and in starchy foods cooked at high temperatures. ACR is considered to be a neurotoxin, genotoxin and carcinotoxin. Previous studies reported that ACR-exposed workers and experimental animals exhibited visual function defects, although the underlying mechanisms have not been elucidated. In this study, we found that zebrafish embryos exposed to 1 mM and 2 mM ACR showed significantly increased reactive oxygen species (ROS), decreased expression of the antioxidant genes Sod1, Sod2, Catalase, Gpx1 and Nrf2, reduced activity of superoxide dismutase (SOD) and catalase, and elevated malondialdehyde (MDA), compared with control embryos. ACR exposure caused loss of both rod and cone photoreceptor cells through Caspase-3-dependent apoptotis. When embryos were simultaneously exposed to ACR and the natural antioxidative substance carnosic acid (CA), the presence of the latter (10 μM) markedly counteracted the above ACR-induced toxic effects. Our data suggest that CA can protect photoreceptor cells against ACR-induced oxidative damage and has a potential for neuroprotection of visual function in humans exposed to ACR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 175, October 2018, Pages 103-114
نویسندگان
, , , , , ,