کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8791923 1602548 2018 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ocular toxicity of reduced graphene oxide or graphene oxide exposure in mouse eyes
ترجمه فارسی عنوان
سمیت چربی از کاهش اکسید گرافین و یا قرار گرفتن در معرض اکسید گرافین در چشم ماوس
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی
With the wide application and mass production of nanoparticle products, environmental nanopollutants will become increasingly common. The eye is an important organ responsible for vision in most living organisms, and it is directly exposed to the atmosphere. Direct contact between the eye and nanoparticles in the environment can potentially lead to ocular damage. However, publications focusing on the eye-damaging potential of nanoparticles are scarce. Therefore, to evaluate the impact of nanoparticles on the eyes, we investigated the ocular toxicity of reduced graphene oxide (RGO) and graphene oxide (GO) using morphological and molecular biological methods in vivo and in vitro in the present work. The findings show that short-term repeated GO exposure can cause obvious intraocular inflammation, an incrassated corneal stromal layer, cell apoptosis in the cornea, iris neovascularization and significant cytotoxicity of rat corneal epithelial cells (rCECs), while RGO causes no significant ocular toxicity in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 174, September 2018, Pages 59-69
نویسندگان
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