کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8794361 | 1602783 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuropathic Corneal Pain
ترجمه فارسی عنوان
درد قرنیه نوروپاتی
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کلمات کلیدی
PHNTMSFDAOSDILDNNCPTGNDEDIVCMCbzRCTTCANGFQOLRandomized controlled trial - آزمایش تصادفی کنترل شدهAST - آسپارتات ترانس آمینازDry eye disease - بیماری چشم خشکTranscranial magnetic stimulation - تحریک مغناطیسی مغزTricyclic antidepressant - داروهای ضدافسردگی سه حلقه ایCNS - دستگاه عصبی مرکزیCAM - ساخت به کمک کامپیوترFood and Drug Administration - سازمان غذا و داروcentral nervous system - سیستم عصبی مرکزیOcular Surface Disease Index - شاخص سطح بیماری چشمnerve growth factor - فاکتور رشد عصبContact lens - لنزهای تماسی، عدسکin vivo confocal microscopy - میکروسکوپ فوکوکال in vivoTrigeminal neuralgia - نورالژی تریزمینال، نورالژی عصب سهقلوpostherpetic neuralgia - نورالژی پسرشپتیکPROSE - پروسهcarbamazepine - کاربامازپینQuality-of-life - کیفیت زندگی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
چشم پزشکی
چکیده انگلیسی
Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage, and evidence-based clinical recommendations for the management of patients with NCP are scarce. The objectives of this review are to provide guidelines for diagnosis and treatment of patients with NCP and to summarize current evidence-based literature in this area. We performed a systematic literature search of all relevant publications between 1966 and 2017. Treatment recommendations are, in part, based on methodologically sound randomized controlled trials (RCTs), demonstrating superiority to placebo or relevant control treatments, and on the consistency of evidence, degree of efficacy, and safety. In addition, the recommendations include our own extensive experience in the management of these patients over the past decade. A comprehensive algorithm, based on clinical evaluation and complementary tests, is presented for diagnosis and subcategorization of patients with NCP. Recommended first-line topical treatments include neuroregenerative and anti-inflammatory agents, and first-line systemic pharmacotherapy includes tricyclic antidepressants and an anticonvulsant. Second-line oral treatments recommended include an opioid-antagonist and opiate analgesics. Complementary and alternative treatments, such as cardiovascular exercise, acupuncture, omega-3 fatty acid supplementation, and gluten-free diet, may have additional benefits, as do potential noninvasive and invasive procedures in recalcitrant cases. Medication selection should be tailored on an individual basis, considering side effects, comorbidities, and levels of peripheral and centralized pain. Nevertheless, there is an urgent need for long-term studies and RCTs assessing the efficacy of treatments for NCP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ophthalmology - Volume 124, Issue 11, Supplement, November 2017, Pages S34-S47
Journal: Ophthalmology - Volume 124, Issue 11, Supplement, November 2017, Pages S34-S47
نویسندگان
Gabriela MD, Sunali MD, Pedram MD, FACS,