Selected Heat-Sensitive Antibiotics Are Not Inactivated During Polymethylmethacrylate Curing and Can Be Used in Cement Spacers for Periprosthetic Joint Infection

The curing temperatures of PMMA in knee spacers are not high enough or maintained long enough to significantly affect the antimicrobial efficacy of ceftazidime, a known “heat-sensitive” antibiotic. Future studies should investigate if more “heat-sensitive” antibiotics could be used clinically in PMMA spacers.