کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8807289 1606596 2018 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nodal T-cell lymphomas with a T-follicular helper cell phenotype
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Nodal T-cell lymphomas with a T-follicular helper cell phenotype
چکیده انگلیسی
The discovery and characterisation of T-follicular helper (TFH) cells, a distinct functional subset of T-helper cells has led to the recognition that some peripheral T-cell lymphomas (PTCLs) have a TFH cell immunophenotype. Due to the overlap in clinical, morphological, immunophenotypic and genetic characteristics, the revised 4th edition to the WHO classification recognises one umbrella category of 'angioimmunoblastic T-cell lymphoma and other nodal TCLs of TFH cell origin'. This review provides a brief overview of TFH cells with special emphasis on function and phenotype and a more detailed discussion of clinical, morphologic, immunophenotypic and genotypic characteristics of AITL, follicular T-cell lymphoma and nodal PTCL with TFH phenotype which constitute nodal TCLs of TFH origin. Secondary B-cell proliferations (often EBV positive) and features that help differentiate reactive lymphoid hyperplasia and other types of lymphoma, including PTCL, NOS and secondary B-cell lymphomas and classic Hodgkin lymphoma, from nodal TCLs with a TFH phenotype are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Histopathology - Volume 24, Issue 7, July 2018, Pages 227-236
نویسندگان
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