Evidence of reduced bladder capacity during nighttime in children with monosymptomatic nocturnal enuresis

A significant proportion of children with MNE and normal MVV during the daytime frequently experienced wet nights, with a NUP well below their MVV and even <65% of EBC. This indicated that bladder reservoir dysfunction during sleep is relatively common in MNE. This abnormality was not reflected on daytime recordings, and thus nighttime data with NUP must be collected. This phenomenon may explain treatment failure to desmopressin, despite adequate antidiuretic response.133Figure. Number of desmopressin responders (%) in the three groups of patients. Patients were defined as frequently reduced eNBC if >40% of wet nights were with NUP